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Basics & Causes
Basics & Causes

Q. Mounjaro 2.5mg is a hot topic lately. How exactly does it work to help with weight loss?

A.

Mounjaro mimics GLP-1 and GIP hormones to stimulate insulin secretion and suppress hunger. The 2.5mg starting dose helps the body adapt before moving to higher doses. It works by delaying gastric emptying to prolong satiety and sending fullness signals to the brain. From a TKM perspective, it controls appetite artificially to slow the accumulation of 'Phlegm-fluid' (Dam-eum), which is considered metabolic waste in the body.

📝 Detailed Answer

Mounjaro functions as a 'dual receptor agonist,' mimicking natural satiety hormones to signal the brain and slow down the stomach's movement. From a Traditional Korean Medicine (TKM) viewpoint, this is quite interesting because by reducing food intake, the medication effectively prevents the buildup of 'Phlegm-fluid' (Dam-eum), the metabolic dregs of the body. However, artificially slowing digestion for long periods can lead to a state of 'Spleen Deficiency' (Bi-heo), where the digestive system's vital energy is depleted, often resulting in chronic bloating and fatigue. While mimicking hormones to reduce intake is efficient, we must be careful not to undermine the body's natural self-healing capacity. I always advise patients to protect the functions of the 'Spleen and Stomach' (Bi-wi) even while using such medications. Combining Mounjaro with TKM treatments to promote 'Qi and Blood circulation' and clear 'Blood Stasis' (Eo-hyeol) can provide a much more stable foundation for maintaining health and preventing the yo-yo effect.
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Dr. Yeonseung Choe

Expert Verified

Dr. Yeonseung Choe

Chief Director

Last reviewed 2026.05.13

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