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Basics & Causes
Basics & Causes

Q. I've heard a lot about obesity treatments like Wegovy lately. How exactly do they work to help with weight loss?

A.

GLP-1 receptor agonists like Wegovy mimic the body's natural GLP-1 hormone to stimulate the satiety center in the brain, reducing appetite and overall food intake. Additionally, they slow down gastric emptying, which prolongs the feeling of fullness after eating. Rather than relying on willpower, these medications work by modulating hormonal signals to naturally decrease consumption.

📝 Detailed Answer

When these medications first hit the market, there was a lot of excitement about whether the struggle with dieting was finally over. However, through clinical experience and patient observation, it became clear that responses vary significantly from person to person, and there is often a gap between theoretical efficacy and actual results. From a modern medical perspective, these drugs act on GLP-1 receptors to send a strong 'I'm full' signal to the brain. However, when integrating this with the perspective of Traditional Korean Medicine (TKM), we must ask: is suppressing appetite unconditionally the right answer? In TKM, obesity and appetite issues are often viewed through the lens of 'Spleen Deficiency' (脾虛), where the organ responsible for digestion and absorption is weakened. If we forcibly suppress the appetite of someone who already lacks vital energy and has poor digestive capacity, the body may lose its ability to produce energy, leading to a collapse in overall metabolism. Furthermore, if a patient has an accumulation of 'Dam-eum' (痰飮, phlegm-fluid retention) or 'Eo-hyeol' (瘀血, blood stasis), forced fasting may lead to weight loss, but it often results in severe lethargy and dizziness. Therefore, my approach is to focus not just on 'how much less' a patient eats, but whether the body is in a state capable of handling the process. To maintain a healthy body and prevent the yo-yo effect, it is crucial to combine appetite control with treatments that restart the 'metabolic engine' and restore the body's internal balance.
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Dr. Yeonseung Choe

Expert Verified

Dr. Yeonseung Choe

Chief Director

Last reviewed 2026.05.12

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